prion
He escaped from prion yesterday.
昨天他从监狱逃跑了。
Could RNA interfere with prion disease?
RNA能否干预普粒子疾病？
Can the "flipped" BSE priori induce the normal human prion to flip?
这种“变形的”BSE普里安能诱发正常人普里安发生改变吗?
Prion diseases can be controlled, if not eradicated.
如果说普朊病难以彻底消除的话,那也是可以控制的。
All rates listed above are subject to change without prion notice.
以上价格如有变动,恕不另行通知。
In prion year whose output value reached 20 million yuan.
上年实现产值2000万元人民币。
Mad cow disease is caused by the misfolding of a small protein called Prion.
该病与羊瘙痒病具有同源性,它们与人类克-雅氏病(Creutzfeldt-Jakobdisease,CJD)均是海绵状脑组织病变,由Prion蛋白引起。
Prion diseases affect the brains of a number of mammals, including humans.
普利子疾病能影响许多哺乳动物的大脑，包括人类。
The Mad Cow Disease (Bovine Spongiform Encephalopathy) is a chronic consumption lethal disease infected by the Prion.
疯牛病 (牛海绵状脑病 )是由朊病毒即传染性蛋白颗粒 ( Prion)引起的一种慢性消耗性致死性的传染病。
A transmissible spongiform encephalopathy of cattle associated with abnormal prion proteins in the brain.
牛海绵状脑病是一种可以在牛中传播的海绵状脑病，与脑组织中异常朊病毒蛋白有关。
We have shown an initial proof of this principle by following the evolution of prion disease in mice.
我们藉由追踪实验小鼠体内普恩蛋白疾病的进展，对这个理论有了初步的验证。
What is een more peculiar: exactly the same prion proteins occur in healthy animals.
更奇特的是：这种蛋白质在健康动物中也存在。
Although the wastewater generated from the experiment was clear of prion protein presence, the biosolids were not.
虽然实验产生的废水中没有朊病毒出现，但废水处理产生的污泥却并非如此。
Until that question is answered, the new era of the prion will remain confusing and frightening.
如果这一问题得不到解答，朊病毒的新时期将仍然充满困惑和恐惧。
There is currently no treatment for prion diseases, which include CJD in humans and boine spongiform encephalopathy (BSE) in cattle.
目前还没有普粒子疾病的治疗办法，包括人类的克雅氏病（CJD）和牛脑海绵状病（疯牛病，BSE）。
The incubation period of prion diseases may span upward of40 years, and CWD has been spreading noticeably in only the past10.
普恩蛋白病变的潜伏期可能长达40年，而慢性消耗病的散播受到注目，还只是过去10年的事。
Researchers have also made some headway in treating a human prion disorder called Creutzfeldt-Jakob disease( CJD), which today is uniformly fatal.
另外，研究人员也在治疗库贾氏症（JD）面取得某些进展，人类的这种普恩蛋白疾病在今天还是无药可治的绝症。
Known as a "prion" this mysterious protein lies at the heart of the 1996 British BSE (Bovine Spongiform Encephalopathy) crisis.
这种名为“普里安”的神秘蛋白质已成为1996年英国牛海绵状脑病(BSE)危机的关注中心。
In this article, we will introduce mad cow disease, prion protein, transmissible spongiform encephalopathy, and Creutzfeldt-Jakob disease (CJD).
本篇文章即由狂牛症著手，浅谈普利旺蛋白质、传染性海绵状脑病变、库贾氏病。
Researchers have also made some headway in treating a human prion disorder called Creutzfeldt-Jakob disease (CJD), which today is uniformly fatal.
另外，研究人员也在治疗库贾氏症（CJD）方面取得某些进展，人类的这种普恩蛋白疾病在今天还是无药可治的绝症。
The incubation period of prion diseases may span upward of 40 years, and CWD has been spreading noticeably in only the past 10.
普恩蛋白病变的潜伏期可能长达40年，而慢性消耗病的散播受到注目，还只是过去10年的事。
Bovine Spongiform Encephalopathy(BSE)is a non inflammatory, fatal, degenerate encephalopathy infected by prion, which can infect to human.
疯牛病是一种由朊病毒感染引起的、非炎性的、致死性的脑退化性疾病 ,并可传染给人。
Now the scientists want to move on and look for alternative sample-taking methods for diagnosing and tracking prion diseases in humans in early stages.
现在，科学家们想继续前进，并寻找其他采样方法，以供诊断和跟踪朊病毒疾病在人类尚处于初期阶段。
Conclusion Prion protein 106-126 peptide can induce apoptosis in differentiated PC12 cells and present cellular toxicity definitely.
结论：朊蛋白106-126肽段能够诱导分化后的PC12细胞凋亡，具有明确的毒性作用。
However, the prion protein in scrapie-infected brain tissue differs from normal prion protein in some of its properties.
然而,在感染羊瘙痒病的大脑组织的普利昂蛋白在某些性质上不同于一般的普利昂蛋白。
As prion proteins multiply, they accumulate within nerve cells, destroying them and eventually causing Brain tissue to become riddled with holes.
随着普利子蛋白质复制,它们积聚在神经细胞里,破坏细胞最终使脑组织变得布满孔洞。
Preious work has shown that mice with their prion gene knocked out remain healthy, and when inoculated with scrapie are protected against the disease1.
先前的工作已经告诉我们，被敲除普粒子基因的老鼠仍然健康，并且当嫁接羊瘙痒病的时候它们能够抵御疾病。
The rarity of prion diseases and the low national consumption of deer and elk (compared with beef) make it hard to draw any firm conclusions.
由于普恩蛋白疾病十分稀少，相对于牛肉，美国对鹿与麋鹿的消费量也较低，因此很难下明确的结论。
Thus, critical aspects of prion conversion are enciphered by subtle differences between small, highly specific recognition elements.
同样是这些序列元素，它们还能决定不同品系的锯蛋白的形成，决定不同物种之间的传输壁垒。
What's more,it suggests a way to overcome the threat of pathogenic organisms on human being`s heath due to keratinase is able to degrade the prion.
角蛋白酶降解朊病毒的研究结果还为战胜威胁人类健康的病原微生物开辟了一条新的途径,使该酶被称之为“今日的蛋白酶”。
This paper reviews the basic feature,chemical structure of prion protein and prion disease,plausible physical functions of PrPc.
介绍了朊病毒的基本特征、化学结构以及可能具有的生理功能:参与神经系统功能的维持;
Prion diseases are always fatal, often, however, not until months after the outbreak of the disease.As yet there is no cure.
朊病毒病是致命的，常常在发病后数月死亡，但是目前还没有有效的治疗方法。
Quinacrine has been administered orally to patients with vCJD and to individuals who have the sporadic or genetic forms of prion disease.
奎纳克林曾以口服方式开给vCJD患者，以及患有偶发性或遗传性普恩蛋白疾病的人们。
Prion diseases are always fatal, often, howeer, not until months after the outbreak of the disease.As yet there is no cure.
朊病毒病是致命的，常常在发病后数月死亡，但是目前还没有有效的治疗方法。
Still, scientists say new forms of prion diseases have arisen lately, and there's concern that they could hop to humans.
尽管如此，科学家说近来出现了一些新的朊病毒疾病，人们担心这些疾病可能会传播到人类身上。
Complementary DNA (cDNA) sequence of Japanese sea bass (Lateolabrax japonicus) prion protein (PrP) encoding gene was cloned and characterized through RT-PCR approach.
采用RT-PCR方法分离了鲈鱼蛋白质感染因子蛋白编码基因序列,并进行了结构分析。
By tweaking the molecule, the team has been able to get it to show different colors depending on the structure of the prion each prion strain emits its own optical fingerprint.
通过调整分子中，该小组已经能够得到它，以显示不同的颜色取决于结构朊病毒每个朊病毒株放射出自己的光学指纹。
Prion diseases is a kind of infectious,sporadic or genetic neurodegenerative disorders in both humans and animals,including scrapie in sheep,BSE in cattle and CJD in humans.
朊病毒疾病是人和动物中的一种传染性、散发性和遗传性的神经退行性脑病。
However, other scientists are skeptical and believe that the prion protein is a viral coat protein that protects a small nucleic acid that has not yet been detected.
然而,另外的科学家表示怀疑，他们相信普利昂蛋白是病毒中用于保护至今还未被检测到小核酸的衣壳蛋白。
Propagation of transmissible spongiform encephalopathies is believed to involve the conversion of the cellular prion protein, PrPC, into a misfolded oligomeric form,PrPSc.
长久以来，系统生物学研究的终极目标在于理解生物体内部机制的运作，以获得所需的重要资讯并建构模型工具。
The history, situation, clinical symptom, detection of BSE, hypothesis of prion and protein, mechanism of BSE were reviewed. And the possibility of curing BSE was elucidated.
摘要论述了疯牛病的发病历史与现状、疯牛病的临床症状与检测、朊蛋白与蛋白假说和疯牛病的致病机理等。此外，还讨论了治愈疯牛病的可能性。
We should transform the traditional medical thinking model to research the mystery of prion.The appearances of prion diseases are discussed from philosophical angle.
必须转变固有的医学思维模式来看待朊病毒之谜,并从哲学角度探讨了朊病毒病的出现。
And the mouse prions were able to change the hamster proteins into a new kind of prion that infected both healthy hamsters and mice.
老鼠朊蛋白能把仓鼠蛋白变为一种新的朊蛋白，这种新的朊蛋白能感染健康的仓鼠和老鼠。
Therefore, many investigators are looking at ways to block prion formation or to boost a cell's ability to clear existing prions.
因此，许多研究人员正在想办法阻断普恩蛋白的形成，或是提升细胞清除既存普恩蛋白的能力。
In mice inoculated with prions in the gut and then given antibodies directed against prion proteins, the incubation period was prolonged.
若将普恩蛋白注入小鼠的肠道，然后再给予针对普恩蛋白的抗体，则潜伏期会延长。
"What is a prion?
什麽是普里昂?
Investigators are also hopeful that when a successful therapy for prion disease is developed, it will suggest effective therapies for more common neurodegenerative diseases, including Alzheimer's, Parkinson's and amyotrophic lateral sclerosis( ALS).
研究人员也怀抱著希望，如果能够发展出有效治疗普恩疾病的方法，将可提供线索来有效治疗其他更常见的神经退化疾病，包括阿兹海默症、金森氏症以及侧索硬化肌萎缩症等。
The prion protein(PRNP) genes of 25 Amur tigers were amplified by PCR using primers designed from mammalian PRNP. These PCR products contain 402 bp encoding 134 amino acids,and have a homology of 99.67%.
根据已报道的哺乳动物朊病毒基因序列设计引物,采用PCR方法扩增了25只东北虎的朊病毒基因,克隆、测序及序列分析表明,所得到的东北虎朊病毒基因片段为402bp,编码134个氨基酸的前体蛋白,核苷酸序列同源性为99.67%。
The evidence is accumulating that prion diseases are due to proteins which change their conformation irreversibly during an association reaction, perhaps by mechanisms related to amyloid accumulation.
越来越多的证据指出蛋白感染素疾病(如狂牛病)是因为蛋白质结合过程中其构型产生不可逆的改变，可能是由类淀粉体堆积相关的机制造成。
Bovine spongiform encephalopathy (BSE) is a non-inflammatory,fatal,degenerate encephalopathy infected by Prion, which can infect to human that cause New Variant Creutzfeldt-jakob disease(nvCJD).
疯牛病即牛海绵状脑病是一种由朊蛋白感染引起的非炎性的致死性的脑退化性疾病 ,并可传染给人 ,引起人类的新型克雅氏病。